Future research should focus on developing animal models that more accurately mimic human AAA to reliably test the effect of drug targets. Improving targeting specificity and minimizing systemic exposure by achieving targeted delivery of nanoparticles or adeno-associated viral vectors could be crucial to enhance efficacy and safety. A well-designed systematic integrated cross-species analysis of single-cell RNA-sequencing data from human AAA and different models of animal AAA could be of value to identify differentially expressed genes across species, highlight conserved therapeutic targets, reveal which AAA induction method appropriately models each aspects of the human disease, and guide the selection of animal models, thereby enhancing translational relevance.
Thanigaimani et al. (Fri,) studied this question.