Sequential In Situ Normothermic Regional Perfusion and Ex Situ Normothermic Machine Perfusion in Controlled Donation After Circulatory Death Liver Transplantation: A Retrospective Single-center Experience | Synapse
March 1, 2026
Sequential In Situ Normothermic Regional Perfusion and Ex Situ Normothermic Machine Perfusion in Controlled Donation After Circulatory Death Liver Transplantation: A Retrospective Single-center Experience
Key Points
The research aims to assess the impact of sequential normothermic perfusion methods on liver graft viability in transplantation post-circulatory death.
Conducted a retrospective single-center analysis of liver transplants after circulatory death.
Implemented sequential in situ normothermic regional perfusion (NRP) and ex situ normothermic machine perfusion (NMP).
Evaluated liver graft parameters and preservation times post-perfusion.
NRP combined with NMP utilized liver grafts with marginal parameters effectively.
Increased preservation time before transplantation was achieved through NMP.
Abstract
NRP and NMP are complementary, with further NMP assessment able to use liver grafts with marginal NRP parameters or facilitating increased preservation time.