Atisara is the abnormal passage of liquid stool, wherein Agnimandya (impaired digestive fire) leading to Ama (unassimilated food) is the root cause. This review examines the Nidanas described in Ashtanga Hridaya from a current medical perspective, highlighting their similarity in concepts with the contemporary disease mechanisms of diarrhoea. Classical Ayurvedic literature elaborates causes such as excessive fluid intake, unaccustomed dietary intake, irregular meal patterns, suppressing urges, regular use of dry meat, sesame, flour preparations, sprouts, and alcohol that closely align with the modern mechanisms, including high osmotic load, dysbiosis, modifications in gut microbiota composition, impairment in digestive function, alteration in gut motility and intestinal permeability and circadian rhythm disruption. Understanding these connections helps physicians in the early detection of these precipitating factors, thereby planning a multidisciplinary management strategy and implementing better choices in patient care.
C. Krishna Devaki1*, Gujjarwar Vidula2, Kushwaha Nidhi3, Sharma Sahil4 (Sun,) studied this question.