Diagnostic accuracy of phosphatase and tensin homolog loss in differentiating between atypical endometrial hyperplasia/endometrioid intraepithelial neoplasia and non-atypical endometrial hyperplasia: A systematic review and meta-analysis.

Key Points

• The research aims to assess the diagnostic accuracy of phosphatase and tensin homolog (PTEN) loss in differentiating atypical and non-atypical endometrial hyperplasia.
• Systematic review and meta-analysis conducted on available studies
• Inclusion of studies focusing on PTEN loss in endometrial lesions
• Evaluation of diagnostic accuracy metrics across studies
• PTEN loss shows significant diagnostic accuracy for atypical endometrial hyperplasia
• Higher sensitivity and specificity in differentiating from non-atypical hyperplasia
• Meta-analysis confirms effectiveness of PTEN loss as a biomarker