Background/Aim: Systemic inflammation influences glioma progression. We evaluated the prognostic value of the white cell-to-lymphocyte ratio (WLR) and aiming to develop a practical survival prediction model. Patients and Methods: Patients with glioma from the INSCOC database were retrospectively analyzed and randomly split into training and validation cohorts (7:3). Kaplan–Meier analysis, restricted cubic splines, and Cox regression assessed associations between WLR and overall survival (OS). A WLR-based nomogram was established and internally validated using calibration and decision curve analysis. Results: The optimal WLR cutoff was 4.182. Patients with WLR ≥4.182 had significantly worse OS (ppConclusion: WLR is an independent, readily available prognostic marker in glioma. A WLR-based nomogram may aid individualized risk stratification and clinical decision-making.
Zhang et al. (Fri,) studied this question.