Targeting the Dynamic Susceptibility Window: Time-Sensitive Photodynamic Synergy With Antibiotics Against Streptococcus spp.

Key Points

• The aim is to determine the optimal timing for photodynamic intervention (PDI) to enhance its synergistic effects with antibiotics against Streptococcus spp.
• Identified specific stages of bacterial response to antibiotic stress.
• Assessed the timing of PDI application in relation to antibiotic treatment.
• Analyzed the effects of PDI on antibiotic efficacy.
• PDI is most effective when applied during critical stages of bacterial response.
• Timing significantly influences the synergy between PDI and antibiotics.
• Findings suggest a potential redefinition of adjuvant treatment strategies.