Endovascular therapy patients with below-the-knee lesions had a 48% higher risk of major adverse limb event at 2 years than those with isolated femoropopliteal lesions (adjusted HR 1.48, 95% CI 1.04-2.10, p=0.028).
Observational (n=690)
No
Does endovascular therapy for below the knee lesions compared to isolated femoropopliteal lesions impact major adverse limb events in patients with chronic limb-threatening ischemia?
In patients with chronic limb-threatening ischemia undergoing endovascular therapy, the presence of below-the-knee lesions is associated with a higher risk of major adverse limb events and cardiovascular mortality compared to isolated femoropopliteal lesions.
Effect estimate: Adjusted HR 1.48 (95% CI 1.04-2.10)
Absolute Event Rate: 60% vs 41.7%
p-value: p=0.028
Aims: The aim of this study is to evaluate the impact of each level atherosclerotic lesion subset on clinical outcomes following EVT in CLTI patients.
Watanabe et al. (Thu,) conducted a observational in Patients with chronic limb-threatening ischemia undergoing successful endovascular therapy for femoropopliteal and/or below-the-knee lesions (n=690). Endovascular therapy vs. Isolated femoropopliteal lesion group vs. below-the-knee lesions group was evaluated on Major adverse limb event (MALE) defined as composite of all-cause death and major amputation at 2 years after EVT (Adjusted HR 1.48, 95% CI 1.04-2.10, p=0.028). Endovascular therapy patients with below-the-knee lesions had a 48% higher risk of major adverse limb event at 2 years than those with isolated femoropopliteal lesions (adjusted HR 1.48, 95% CI 1.04-2.10, p=0.028).