A Case of Anaplastic Thyroid Carcinoma in a 90-year-old Patient Successfully Treated with a Combination of Dabrafenib and Trametinib

Key Points

• This report aims to present the treatment and outcomes of a 90-year-old patient with anaplastic thyroid carcinoma.
• Patient presented with a rapidly enlarging left neck mass and was diagnosed via CT and biopsy.
• Genetic testing revealed a positive BRAF V600E mutation.
• The patient was treated with a combination of Dabrafenib and Trametinib.
• Monitoring included physical examinations and CT scans to assess tumor response.
• Significant tumor shrinkage and pain improvement were observed within one week.
• CT scan two months after treatment indicated marked reduction in tumor size and lymph node metastasis.
• Grade 1 fever occurred but was manageable with medication and required no dose adjustments.