Background: This study aimed to analyze the clinical and ultrasonographic features of 6 pathologically confirmed cases of uterine inflammatory myofibroblastic tumors (UIMT) and to enhance clinicians’ ability to achieve timely diagnosis and treatment. Methods: This retrospective case series included 6 patients with pathologically confirmed UIMT who were admitted to our hospital between January 2019 and January 2025. Clinical, ultrasonographic, and pathological data were collected and analyzed retrospectively. Results: All 6 tumors were solid and originated from the myometrium. 3 were confined to the myometrium, 2 extended toward the submucosa, and 1 toward the subserosa. 5 lesions were hypoechoic and 1 was hyperechoic, all showing heterogeneous internal echoes and a characteristic “blurred halo sign”. The median maximum diameter was 6.9 cm. Color Doppler flow imaging (CDFI) showed an Adler grade ≥2, demonstrating a “colorful mosaic sign”. During follow-up, 2 lesions increased in size by 1 cm and 2 cm, respectively, within 2–4 months. No extrauterine metastasis was observed. All cases were positive for anaplastic lymphoma kinase (ALK), as confirmed by fluorescence in situ hybridization (FISH). All patients underwent surgical treatment, including 1 total hysterectomy and 5 local resections. No recurrence or metastasis was observed during 21–57 months of follow-up. Conclusions: UIMT exhibits characteristic sonographic features, including solid masses with heterogeneous internal echoes (“blurred halo sign”) and abundant blood flow signals (“colorful mosaic sign”). Recognizing these distinctive imaging patterns is critical for improving diagnostic accuracy and guiding appropriate clinical management.
Miao et al. (Tue,) studied this question.