METTL16 Modulates GPX4 Expression to Regulate Chondrocyte Ferroptosis

Key Points

• This research investigates how METTL16 influences GPX4 expression and ferroptosis in chondrocytes.
• Assessed the effects of METTL16 overexpression on chondrocyte survival.
• Measured GPX4 mRNA levels using m6A modification analysis.
• Evaluated bone growth outcomes in chondrocyte models.
• METTL16 overexpression significantly increased GPX4 expression.
• Bone growth was enhanced in models with elevated METTL16 levels.
• Ferroptosis in chondrocytes was alleviated by improved GPX4 expression.