Objective: This study aimed to evaluate the cytotoxic and apoptosis-inducing effects of lisinopril and amlodipine in a human hepatocellular carcinoma (Hep3B) cell model. Materials and Methods: The cytotoxic effects of Hep3B cells treated with lisinopril and amlodipine were assessed using the MTT assay. Cell viability was analyzed at 24, 48, and 72 hours, and IC₅₀ values were calculated. Apoptosis-related gene expression levels, including Bcl-2, Bcl-xL, Bax, and Bak, were determined using RT-qPCR. Statistical analyses were performed using one-way ANOVA, and differences with p
Avcıkurt et al. (Sat,) studied this question.