New phenotype and outcomes in connective tissue disease-associated pulmonary arterial hypertension: relevance of age-related comorbidities

Key Points

• The study aims to explore the phenotype and outcomes of pulmonary arterial hypertension in patients with connective tissue disease, focusing on age-related comorbidities.
• Analyzed data from the REHAP registry
• Compared their profiles with idiopathic pulmonary arterial hypertension (IPAH) patients
• Evaluated treatment approaches based on age-related comorbidities
• CTD-PAH patients are older than IPAH patients
• CTD-PAH patients have a lower burden of comorbidities
• Survival rates for CTD-PAH and IPAH are similar up to five years
• Chronic kidney disease (CKD) is identified as a key prognostic factor