Causal links between gut microbiota, plasma metabolites, and insomnia: Insights from Mendelian randomization.

Key Points

• The aim is to explore how gut microbiota affects insomnia risk through plasma metabolites.
• Utilized Mendelian randomization to analyze genetic influences on gut microbiota and insomnia
• Assessed the relationship between plasma metabolites and insomnia risk
• Evaluated the gut-brain axis connections
• Identified specific plasma metabolites linked to insomnia risk
• Demonstrated a causal pathway from gut microbiota to insomnia via metabolites
• Provided insights into potential therapeutic targets for sleep disorders