Integrative analysis of T cell subset-specific ICOS expression and tumor HLA class I/II expression in lung adenocarcinoma: implications for their interaction and clinical outcome

Key Points

• To explore the relationship between ICOS expression in T cell subsets and tumor HLA expression in lung adenocarcinoma and its implications for clinical outcomes.
• Analyzed ICOS+ T cell density in lung adenocarcinoma tumor samples.
• Evaluated the correlation between ICOS+CD4+ non-Treg cells and HLA expression levels.
• Assessed the association between tumor HLA expression and patient prognosis.
• ICOS+ TIL density correlates with increased presence of ICOS+CD4+ non-Treg cells in tumors.
• Higher HLA-DR expression in tumors is linked to better patient prognosis.
• ICOS expression may have variable clinical relevance depending on tumor context.