Does aspirin-phosphatidylcholine (PL2200) reduce mucosal damage and acute gastroduodenal ulcers in at-risk subjects compared to low-dose aspirin?
Aspirin-phosphatidylcholine (PL2200) attenuates aspirin-induced mucosal damage, offering a potential gastroprotective alternative for older patients requiring low-dose aspirin.
Low-dose aspirin induced a surprisingly high incidence of acute gastroduodenal ulcers in at risk subjects, highlighting that aspirin's upper GI risk begins early and may require gastroprotection. Local mechanisms of GI protection are important as aspirin's preassociation with surface-active phospholipids significantly reduced mucosal damage. PL2200 may be an attractive alternative or complement to proton pump inhibitors in older patients who are at risk of aspirin-induced ulceration. Longer-term studies assessing clinical GI events are desirable to confirm the clinical GI safety profile of PL2200.
Cryer et al. (Tue,) studied this question.
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