KEGG analysis revealed significant enrichment of ribosome, actin cytoskeleton regulation, and focal adhesion pathways among the upregulated differentially expressed phosphoproteins (DEPPs) from the PH/NH and PII/PH comparisons, whereas spliceosome alterations were observed among upregulated DEPPs of PH/NH and downregulated DEPPs of PII/PH. This study has identified several candidate molecules awaiting further validation, including the phosphorylated proteins IQGAP1 and VIM, as well as the kinases ERK and GSK3α, which may be implicated in the progression of LC.
Wu et al. (Sat,) studied this question.