The cleaning of process and environmental residues is a crucial aspect of contamination control strategy (CCS) and is mandated by several cGMP regulations. Environmental residues, which remain on surfaces post-disinfection, can accelerate the deterioration of manufacturing area surfaces and pose safety hazards, such as slip and fall risks for operators. The accumulation of environmental residues can also have an impact on the performance of disinfectants and may harbor microorganisms.This study evaluated textiles and rinsing agents and the combined effect they had on the removal of disinfectant residues on various common cleanroom surfaces. Variables included different cleaning solutions and a range of cleaning textiles (mops/wipes) with diverse substrates and textile constructions. The evaluation was conducted quantitatively by incorporating a fluorescent tracer dye into the disinfectant. Pixel analysis measured surface residue after the disinfectant was applied and dried. Subsequently, combinations of cleaning solutions and substrates were used to remove the disinfectant residue, and pixel analysis was performed again to determine the remaining residue.This poster will present the data visually, to provide insight into the considerations that must be made when establishing a residue removal regimen in critical cleanroom spaces.
Lauren Pernot (Thu,) studied this question.