STS score and LV diastolic-systolic diameter difference independently predicted 10-year survival after TAVR with HR 2.244 and 1.223 respectively in high-risk patients with severe aortic stenosis.
Cohort (n=15)
No
Baseline STS score and left ventricular diastolic-systolic diameter difference independently predict 10-year survival after TAVR, emphasizing the prognostic value of precise pre-procedural clinical and echocardiographic evaluation.
Effect estimate: HR 2.244 for STS score, HR 1.223 for LV diastolic-systolic diameter difference (95% CI STS score 95% CI: 1.39-16.92; LV diameter difference 95% CI: 1.06-1.68)
p-value: p=STS score p=0.012; LV diastolic-systolic diameter difference p=0.032
Aim: This study aimed to identify predictors of 10-year survival in patients undergoing early Transcatheter Aortic Valve Replacement (TAVR) with the first-generation CoreValve system, providing insights from a pioneering single-center experience in Turkey.Material and Methods: We retrospectively analyzed high-risk patients who underwent TAVR between April 2012 and March 2013. Baseline clinical characteristics and echocardiographic parameters were compared between survivors and non-survivors over a 10-year follow-up period. Survival analysis was performed using Kaplan-Meier curves, and Cox regression models were utilized to identify independent predictors of survival.Results: The cohort included patients with a mean age of 77.1 ± 7.7 years. The Kaplan–Meier analysis estimated the median survival time at 62 months (95% CI: 33–127), with a mean survival time of 71.6 months (95% CI: 43.9–99.3). Survivors exhibited significantly lower left ventricular (LV) end-diastolic diameter, LV mass index, and LV diastolic-systolic diameter difference compared to non-survivors. In univariate analysis, STS score, pulmonary artery pressure (PAP), LV hypertrophy pattern, LV diameter difference, and LV mass index emerged as potential predictors of long-term survival. STS score and LV diameter difference were independent predictors.Conclusion: In this study, both STS score and LV diastolic-systolic diameter difference were identified as independent predictors of 10-year survival following TAVR. These findings emphasize the critical role of precise patient evaluation and underscore the potential value of personalized procedural strategies to optimize long-term outcomes in TAVR patients
Hoşoğlu et al. (Sun,) conducted a cohort in High-risk patients with symptomatic severe aortic stenosis undergoing early Transcatheter Aortic Valve Replacement with first-generation CoreValve system (n=15). Transcatheter Aortic Valve Replacement with first-generation CoreValve system was evaluated on 10-year all-cause mortality (HR 2.244 for STS score, HR 1.223 for LV diastolic-systolic diameter difference, 95% CI STS score 95% CI: 1.39-16.92; LV diameter difference 95% CI: 1.06-1.68, p=STS score p=0.012; LV diastolic-systolic diameter difference p=0.032). STS score and LV diastolic-systolic diameter difference independently predicted 10-year survival after TAVR with HR 2.244 and 1.223 respectively in high-risk patients with severe aortic stenosis.