LDLR and APOB pathogenic variants predict discordant TSH effect on LDL-C

Key Points

LDL-C levels were positively associated with TSH exclusively in patients with LDLR variants, suggesting genetic influences.
This study highlights that TSH may not have the same effect on LDL-C levels in APOB carriers as it does in LDLR variants.
Through observing familial hypercholesterolemia cases, the research shows a connection between genetic background and hormonal sensitivity.
Attention to thyroid hormone levels may enhance understanding of cholesterol management in LDLR-FH patients.

Abstract

TSH was positively associated with LDL-C only in FH due to LDLR variants, not in APOB carriers. These findings suggest that genetic background may shape hormonal sensitivity, and that attention to thyroid status could be particularly relevant in LDLR-FH.

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Cite This Study

Kafol et al. (Tue,) studied this question.

synapsesocial.com/papers/69a759e1c6e9836116a1f456 https://doi.org/https://doi.org/10.1016/j.atherosclerosis.2026.120672

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