Zhen-Wu-Tang ameliorates renal fibrosis and tissue stiffness in a murine lupus model, an effect associated with the suppression of fibroblast-to-myofibroblast transition

Key Points

• Zhen-Wu-Tang significantly reduces renal fibrosis and tissue stiffness in a murine model of lupus, showing therapeutic promise.
• The study highlights a marked suppression of fibroblast-to-myofibroblast transition, with key improvements observed.
• Analysis involved a murine model to assess the efficacy of Zhen-Wu-Tang on renal fibrosis in lupus.
• Further validation is necessary in human trials to confirm these effects and explore broader applications.