Prenatal PFHxS exposure alters ovarian development in female adolescent mice: Transcriptomic, hormonal, and structural evidence of disrupted steroidogenesis

Key Points

• Disrupted steroidogenesis indicates significant hormonal changes in the ovarian development process.
• Key evidence shows that prenatal exposure to PFHxS affected ovarian structure and gene expression in adolescent mice.
• Assessment involved transcriptomic analysis of ovarian tissues, revealing altered gene pathways involved in reproductive health.
• Findings signal a need for further investigation into the long-term impacts of toxicant exposures on female reproductive systems.