Identification of the genetic basis of a CO2-dependent Staphylococcus aureus small-colony variant isolated from pacemaker leads

Key Points

• The identification of genetic variants sheds light on co2-dependent metabolic pathways affecting Staphylococcus aureus.
• Small-colony variants have been linked to infections associated with pacemaker leads, posing unique challenges for treatment.
• Genomic analysis was performed to uncover the genetic basis underlying the co2-dependent behavior of these variants.
• Understanding the genetic foundation may enable development of targeted therapies for persistent Staphylococcus aureus infections.