Systemic coagulation and fibrinolytic alterations in eosinophilic asthma with and without nasal polyps

Key Points

• Eosinophilic asthma with nasal polyps shows significant hemostatic alterations, indicating distinct Systemic regulation.
• The study found shorter activated partial thromboplastin time (aPTT) and higher plasminogen activator inhibitor-1 (PAI-1) levels.
• Observational analysis comparing hemostatic markers between eosinophilic asthma phenotypes revealed vital differences.
• The findings highlight the potential implications for targeted therapies and understanding systemic hemostasis in distinct asthma subtypes.