Beyond circulating cGMP: revisiting compartmentalized signaling in HFrEF

Key Points

• Compartmentalized signaling significantly affects cGMP levels in heart failure.
• The study shows alterations in cGMP pathways with implications for heart function.
• Analysis of compartmentalized signaling mechanisms in heart failure with reduced ejection fraction was conducted.
• This highlights the need for targeted interventions in cGMP signaling pathways.