Paeoniflorin alleviates urushiol-induced pruritus in mice by inhibiting Erk/CCL2 pathway

Key Points

• Paeoniflorin significantly reduces pruritus in mice through the inhibition of the Erk/CCL2 pathway.
• The study observed a notable decrease in itch scores, showcasing the effectiveness of the intervention.
• Analysis focused on urushiol-induced pruritus in mice using various behavioral assessments.
• This highlights the need for further exploration in humans to validate these promising findings.