Radiofrequency therapy attenuates hypertrophic scar formation in rabbit ears by modulating the TGF-β1/Smad3 signaling pathway

Key Points

• Radiofrequency therapy effectively reduces hypertrophic scars in rabbit ears, showing potential for treating similar conditions in humans.
• Treatment resulted in significant modulation of the TGF-β1/Smad3 signaling pathway, crucial for scar formation.
• Analysis using animal models indicates a robust mechanism that may translate to clinical practice.
• The findings support the use of radiofrequency therapy as a promising intervention for managing skin scarring in future studies.