Radioguided Occult Lesion Localization (ROLL) and Radioactive Seed Localization (RSL) versus Wire-guided Localization (WGL) in Breast-conserving Surgery for Non-Palpable Breast Cancer: a Systematic Review and Meta-analysis of Randomized Controlled Trials | Synapse
March 3, 2026
Radioguided Occult Lesion Localization (ROLL) and Radioactive Seed Localization (RSL) versus Wire-guided Localization (WGL) in Breast-conserving Surgery for Non-Palpable Breast Cancer: a Systematic Review and Meta-analysis of Randomized Controlled Trials
Key Points
Radioguided localization techniques improve surgical outcomes compared to traditional wire-guided localization.
In meta-analysis, patients undergoing radioguided procedures showed a decrease in re-excision rates by approximately 30%.
Systematic review assessed randomized controlled trials across multiple healthcare centers, ensuring diverse patient data.
Findings suggest a shift towards radioguided techniques may enhance breast-conserving surgery effectiveness, but require further validation.