CRISPR/Cas12a-activated nanozyme-Aptasensor for ultrasensitive colorimetric detection of ochratoxin a based on MOF@pt@MOF nanostructures

Key Points

• Ultrasensitive detection of ochratoxin A is achievable with a novel nanozyme aptasensor.
• The proposed method demonstrates a colorimetric detection capability alongside CRISPR/Cas12a activation.
• This study employs MOF@pt@MOF nanostructures for enhanced sensor performance and specificity.
• Improvement in detection limits may substantially benefit food safety protocols and monitoring.