Design-led synthesis and multidimensional evaluation of novel thiadiazoles as multitarget anti-Alzheimer agents: kinetics, DFT and in silico mapping

Key Points

• Thiadiazoles exhibit significant potential as multitarget anti-Alzheimer agents, addressing various disease mechanisms.
• In kinetic evaluations, new compounds displayed improved inhibition rates compared to existing therapies.
• Analysis using density functional theory (DFT) provided critical insights into molecular behavior and interactions.
• This research highlights promising targets for future drug development, suggesting a multifaceted approach to Alzheimer's treatment.