Clinical and Microbiological Characteristics of macrolide-resistant Bordetella pertussis Infection: A case series in Osaka, Japan (2024–2025)

Key Points

• Macrolide-resistant bordetella pertussis infections present distinct clinical characteristics, complicating diagnosis and treatment.
• A total of 15 cases were analyzed for their clinical and microbiological response to antibiotic treatment.
• Observational analysis revealed the presence of specific symptoms linked to macrolide resistance in patients with this infection.
• These findings underscore the need for updated treatment guidelines addressing rising antibiotic resistance issues.