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Sclerostin-targeted delivery of PCSK9 siRNA reverses osteoporosis in OVX mice | Synapse
March 3, 2026
Sclerostin-targeted delivery of PCSK9 siRNA reverses osteoporosis in OVX mice
HW
Hongling Wu
LH
Liyuan Huang
FS
Fangfang Song
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Key Points
Reversal of osteoporosis observed following targeted delivery of PCSK9 siRNA.
Ovariectomized (OVX) mice showed significant improvements in bone density metrics.
Targeted delivery approach enhances siRNA efficacy in disrupting sclerostin pathways.
This research highlights the potential of targeting specific molecular pathways for therapeutic interventions.
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Wu et al. (Tue,) studied this question.
synapsesocial.com/papers/69a75b73c6e9836116a22c9f
https://doi.org/https://doi.org/10.1016/j.bone.2026.117808