Upregulated expressions of caspase-4 and -5 upon challenging with periodontal microorganisms in human gingival epithelial cells

Key Points

• Caspase-4 and -5 expressions are significantly elevated when challenged with periodontal microorganisms.
• The increase in caspase-4 and -5 was observed in human gingival epithelial cells (HGECs) under these conditions.
• Analysis was performed on human gingival epithelial cells exposed to periodontal microorganisms over a specified time frame.
• These findings imply a possible role for caspases in the immune response to oral pathogens.