Dissemination of integrons and carbapenemase-encoding genes among multidrug resistant Proteus mirabilis isolated from urinary tract infections in Egypt

Key Points

• Multidrug resistant Proteus mirabilis strains often carry integrons and carbapenemase genes, complicating treatment options.
• Rates of multidrug resistance reached over 50%, suggesting a significant challenge for managing urinary tract infections in the region.
• Observational analysis of clinical samples identified key genetic factors associated with antibiotic resistance underlined by integron presence.
• Findings call for enhanced surveillance and control measures to manage the spread of resistant strains that may lead to treatment failures.