A Bacteroides synthetic biology toolkit to build an in vivo malabsorption biosensor

Key Points

• The developed biosensor indicates malabsorption with specific genetic circuits, demonstrating effective diagnostic potential.
• Key evidence shows that the biosensor accurately detects malabsorption in vivo, with potential applications in clinical settings.
• Synthetic biology methods were employed to engineer Bacteroides for the creation of the biosensor, focusing on genetic modifications.
• This biosensor may enable innovative diagnostic approaches for malabsorption conditions, expanding healthcare options.