Intestinal organoids screening reveals: 3BDO as an inhibitor of porcine coronaviruses entry by targeting IFITM3

Key Points

• 3BDO significantly inhibits the entry of porcine coronaviruses into intestinal organoids, illustrating a promising method to combat viral infections.
• The analysis demonstrated that targeting IFITM3 plays a crucial role in mitigating coronavirus entry, with notable efficacy observed.
• Screening of intestinal organoids led to the identification of 3BDO as an effective inhibitor, highlighting its potential clinical application.
• These findings may enable new therapeutic avenues for preventing porcine coronavirus infections; further validation in live models is needed.