GSH-triggered release of anabasine in mitochondria for synergistic chemotherapy assisted by OATP transportation

Key Points

Enhanced apoptosis occurs from anabasine release in mitochondria, driving synergistic effects against tumors.
The GSH-triggered mechanism allows for targeted drug delivery via OATP transportation in tumor cells.
Therapeutic effects are driven by ferritinophagy, indicating mitochondrial engagement in the treatment process.
This approach highlights potential for improving chemotherapy outcomes by combining prodrugs with mitochondrial targeting.

Abstract

• A GSH-triggered prodrug targeting tumor cell mitochondria via OATP-mediated uptake. • Release of a parent drug through an GSH-triggered S N Ar mechanism. • Translation of a nicotinic acetylcholine receptor to an antitumor drug. • Anabasine in mitochondria and induce a synergistic ferritinophagy and apoptosis.

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Cite This Study

Zhang et al. (Thu,) studied this question.

synapsesocial.com/papers/69a75bbac6e9836116a2399c https://doi.org/https://doi.org/10.1016/j.jpha.2026.101565

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