Integrated single-cell analysis with experimental validation reveals ANXA2 as a therapeutic target for ferroptosis in inflammatory bowel disease

Key Points

• ANXA2 expression is linked to ferroptosis in inflammatory bowel disease, indicating its role as a potential therapeutic target.
• Increased fibroblast levels of ANXA2 highlight its significance in the pathogenesis of inflammatory bowel disease.
• Integrated single-cell analysis coupled with experimental validation confirms the relevance of ANXA2 in disease mechanisms.
• Targeting ANXA2 may lead to new treatment strategies for inflammatory bowel disease, underscoring the importance of ferroptosis in therapy.