Benzimidazole and Benzimidazole Derivatives as Anticancer Scaffolds: A Review of Synthetic Approaches

Key Points

• Benzimidazole scaffolds demonstrate promising bioactivity in anticancer drug development, enhancing therapeutic effectiveness.
• Key synthetic methodologies show efficiency, enabling the creation of potent anticancer agents with desirable properties.
• Structure-activity relationships reveal insights into how modifications can improve the anticancer efficacy of these compounds.
• The findings solidify the role of benzimidazoles, calling for their continued exploration in medicinal chemistry.