Start
Entdecken
nav.journalClub
Trends
Mehr
synapse
⌘+K
Sprache
Deutsch
Deutsch
March 3, 2026
CCL25/CCR9-induced M2 macrophage polarization promotes lung cancer progression via TGF-β1-mediated activation of the JAK/STAT-PIM2 signaling pathway
QW
Qiang Wen
YY
Yi Yuan
ZL
Zhihua Liu
See all
Key Points
M2 macrophage polarization significantly promotes lung cancer progression, indicating a crucial role in tumor dynamics.
Activation of the JAK/STAT-PIM2 signaling pathway enhances this promotion, potentially serving as a therapeutic target.
CCL25 and CCR9 are key players in this process, altering the tumor microenvironment to favor cancer growth.
Insights call for further exploration of targeted therapies that inhibit this signaling pathway to slow lung cancer progression.
Mark Helpful
Like
Save
Bookmark
Relay
Share
Mark Helpful
Like
Save
Bookmark
Relay
Share
Cite This Study
Copy
Wen et al. (Wed,) studied this question.
synapsesocial.com/papers/69a75c0cc6e9836116a2470a
https://doi.org/https://doi.org/10.1007/s11010-026-05489-y
CCL25/CCR9-induced M2 macrophage polarization promotes lung cancer progression via TGF-β1-mediated activation of the JAK/STAT-PIM2 signaling pathway | Synapse