Design, synthesis, and evaluation of artesunate-benzofuran hybrids as dual anticancer and anti-inflammatory candidates: In silico profiling and in vitro validation in Caco-2, HepG2, Ishikawa, and RAW 264.7 cell lines
Key Points
Dual anticancer and anti-inflammatory activity was observed across multiple cell lines, indicating potent therapeutic effects.
Key evidence shows significant inhibition of cancer cell proliferation and inflammation in tested lines like Caco-2 and HepG2.
In silico profiling guided the design, synthesis, and evaluation of artesunate-benzofuran hybrids for efficacy.
These findings highlight the potential of such hybrids, paving the way for future research into their clinical application.
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Design, synthesis, and evaluation of artesunate-benzofuran hybrids as dual anticancer and anti-inflammatory candidates: In silico profiling and in vitro validation in Caco-2, HepG2, Ishikawa, and RAW 264.7 cell lines | Synapse