In the preoperative setting, transcriptomic testing can inform whether patients are best suited for active surveillance, lobectomy, or total thyroidectomy. Postoperatively, it sharpens decisions around completion surgery, radioactive iodine use, and the intensity of TSH suppression. Integrating transcriptomic data into clinical decision-making enables more precise selection for treatment escalation or de-escalation. To unlock the full potential of transcriptome-guided management in PTC, prospective validation and adoption into ATA and NCCN guidelines will be critical.
Harvey et al. (Wed,) studied this question.