Ginsenoside Rf promotes testosterone synthesis through the cAMP/PKA/CREB signaling pathway to improve obesity-related male hypogonadism

Key Points

• Testosterone synthesis significantly increases with ginsenoside Rf treatment, supporting its role in managing hypogonadism.
• Increased testosterone levels were observed, with a notable mechanism involving the cAMP/PKA/CREB signaling pathway.
• Analysis revealed that the cAMP/PKA/CREB pathway is crucial for testosterone production in male obesity cases.
• These findings highlight ginsenoside Rf's potential to address obesity-related hormonal imbalances.