Yishen Xiaoke Formula Delays Renal Fibrosis in Diabetic Nephropathy Rats by Inhibiting the TGF-β1/Notch Signaling Pathway

Key Points

Renal fibrosis is delayed in diabetic nephropathy rats treated with Yishen Xiaoke Formula.
TGF-β1 and Notch signaling pathways are key targets for this regulatory effect on fibrosis.
Observational analysis using STZ-induced diabetic nephropathy rat models allows for in-depth mechanism exploration.
This research highlights promising therapeutic avenues but requires further validation in clinical settings.

Abstract

This study will employ the internationally recognized left nephrectomy combined with STZ-induced DN rat model to investigate the regulatory effect of YSXKF on the TGF-β1/Notch signaling pathway and its molecular mechanism in delaying renal fibrosis.

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Federal Institute for Risk Assessment (Wed,) studied this question.

synapsesocial.com/papers/69a75c78c6e9836116a2562f https://doi.org/https://doi.org/10.17590/asr.0000426

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