Oscillatory phases derived from heart rhythms provide effective timing information that may be useful for closed-loop auditory stimulation and reflect brain-heart coupling during sleep. A multidimensional phase-based approach that integrates EEG slow oscillations with instantaneous heart rate phases may support more precise control and stronger enhancement of deep sleep than unimodal approaches, suggesting a new framework for closed- loop neuromodulation.
Sardooeinasab et al. (Fri,) studied this question.