Trajectories of serum HIF-1α and BNIP3 are associated with injury severity and outcomes in pediatric traumatic brain injury: a prospective cohort study

Key Points

• Outcomes correlate with serum levels of hif-1α and bnip3, suggesting their roles in injury severity.
• Significant changes in hif-1α and bnip3 levels were observed in pediatric traumatic brain injury cases.
• Prospective cohort analysis tracked serum biomarkers alongside injury outcomes and severity scores.
• Findings indicate that these biomarkers may serve as indicators for assessing injury impact in children.