A dose-response relationship between low-density lipoprotein cholesterol levels within the normal range and the incidence of diabetes mellitus: a retrospective cohort study

Key Points

• Higher LDL cholesterol levels within the normal range increase diabetes risk significantly, indicating a direct relationship between cholesterol and diabetes onset.
• Individuals with LDL cholesterol levels below 1.8 mmol/L may experience a reduced risk of developing diabetes, highlighting a protective threshold.
• This retrospective cohort analysis examined the incidence of diabetes in relation to LDL cholesterol levels in individuals with normal ranges.
• These findings suggest that refining primary prevention strategies by monitoring LDL-C could play an essential role in diabetes prevention.