Causal association between multiple sclerosis and trigeminal neuralgia: A Mendelian randomization study with meta-analysis

Key Points

• Genetic predisposition to multiple sclerosis contributes to the development of trigeminal neuralgia, highlighting a causal association.
• The analysis included findings from multiple populations, improving the robustness of the association identified.
• Employing Mendelian randomization, the study assessed genetic variants to infer causality between the two neurological conditions.
• The findings underscore the need for further exploration of biological pathways to validate and understand this association.