Neuropathological links between plasma p-Tau 181, white matter hyperintensity, and structural brain changes in aging

Key Points

• Severe white matter hyperintensity is associated with caudate nucleus enlargement, indicating potential brain changes.
• The study shows that elevated plasma p-Tau 181 levels are linked to these structural brain changes, emphasizing mixed pathologies.
• Observational analysis highlighted that WMH might partially mediate the association between plasma p-Tau 181 and superior structures.
• Implications suggest early vascular risk control may improve outcomes associated with aging-related brain changes.