Crocin and eugenol enhance radiosensitivity in oral squamous cell carcinoma cells via apoptotic pathways and cell cycle regulation. Type of study: in vitro

Key Points

• Eugenol and crocin significantly enhance radiosensitivity in oral squamous cell carcinoma cells, leading to apoptosis.
• The study identifies the regulation of apoptotic factors as a crucial mechanism for improving treatment outcomes.
• Observational analysis suggests both compounds promote cell cycle regulation and checkpoint arrest to facilitate enhanced sensitivity.
• These findings support the potential of these natural compounds as safe adjuncts for improving radiotherapy effectiveness.