Apigenin ameliorates postoperative inflammation and accelerates wound healing in a rat model of perianal abscess by targeting the JAK1/STAT3 pathway in macrophages

Key Points

• Apigenin enhances wound healing, significantly reducing postoperative inflammation triggered by macrophages.
• The study indicates a notable decrease in inflammatory markers linked to the JAK1/STAT3 pathway with apigenin treatment.
• Analysis involved a rat model of perianal abscess to assess the effects of apigenin on inflammation and healing dynamics.
• The findings support the potential of apigenin as a natural immunomodulator, warranting further investigation of its clinical applications.